The following are a small selection from the growing published literature supporting Micregen’s claims. The Micregen team are shown in bold.

Camussi, G., M. C. Deregibus and V. Cantaluppi (2013). “Role of stem-cell-derived microvesicles in the paracrine action of stem cells.” Biochem Soc Trans 41(1): 283-287.

Fischer, U. M., M. T. Harting, F. Jimenez, W. O. Monzon-Posadas, H. Xue, S. I. Savitz, G. A. Laine and C. S. Cox, Jr. (2009). “Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect.” Stem Cells Dev 18(5): 683-692.

Gnecchi, M., Z. Zhang, A. Ni and V. J. Dzau (2008). “Paracrine mechanisms in adult stem cell signaling and therapy.” Circ Res 103(11): 1204-1219.

Haque N., A. B. J. J., Kasim N. H. A. (2018). Secretome: Pharmaceuticals for cell-free regenerative therapy in stem cell drugs – A new generation of biopharmaceuticals.

Henig, I. and T. Zuckerman (2014). “Hematopoietic stem cell transplantation-50 years of evolution and future perspectives.” Rambam Maimonides Med J 5(4): e0028.

Ho, T. T., M. R. Warr, E. R. Adelman, O. M. Lansinger, J. Flach, E. V. Verovskaya, M. E. Figueroa and E. Passegué (2017). “Autophagy maintains the metabolism and function of young and old stem cells.” Nature 543(7644): 205-210.

Kusuma, G. D., J. Carthew, R. Lim and J. E. Frith (2017). “Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect.” Stem Cells Dev 26(9): 617-631.

Lener, T., M. Gimona, L. Aigner, V. Börger, E. Buzas, G. Camussi, N. Chaput, D. Chatterjee, F. A. Court, H. A. Del Portillo, L. O’Driscoll, S. Fais, J. M. Falcon-Perez, U. Felderhoff-Mueser, L. Fraile, Y. S. Gho, A. Görgens, R. C. Gupta, A. Hendrix, D. M. Hermann, A. F. Hill, F. Hochberg, P. A. Horn, D. de Kleijn, L. Kordelas, B. W. Kramer, E. M. Krämer-Albers, S. Laner-Plamberger, S. Laitinen, T. Leonardi, M. J. Lorenowicz, S. K. Lim, J. Lötvall, C. A. Maguire, A. Marcilla, I. Nazarenko, T. Ochiya, T. Patel, S. Pedersen, G. Pocsfalvi, S. Pluchino, P. Quesenberry, I. G. Reischl, F. J. Rivera, R. Sanzenbacher, K. Schallmoser, I. Slaper-Cortenbach, D. Strunk, T. Tonn, P. Vader, B. W. van Balkom, M. Wauben, S. E. Andaloussi, C. Théry, E. Rohde and B. Giebel (2015). “Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper.” J Extracell Vesicles 4: 30087.

Lopez-Otin, C., M.A. Blasco, L. Partridge and M. Serrano (2013). “The Hallmarks of Aging.” Cell Volume 153, Issue 6, P1194-1217.

Loukogeorgakis SP, De Coppi P. Concise Review: “Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications.” Stem Cells. 2017 Jul;35(7):1663-1673. doi: 10.1002/stem.2553. PMID: 28009066.

Maldonado, E., S. Morales-Pison, Urbina, F. and A. Solari (2023) “Aging Hallmarks and the Role of Oxidative Stress”. Antioxidants, 12(3), 651

Mara Cananzi & Paolo De Coppi (2012) “CD117+ Amniotic Fluid Stem Cells”, Organogenesis, 8:3, 77-88, DOI: 10.4161/org.22426.

Mellows, B., R. Mitchell, M. Antonioli, O. Kretz, D. Chambers, M. T. Zeuner, B. Denecke, L. Musante, D. L. Ramachandra, F. Debacq-Chainiaux, H. Holthofer, B. Joch, S. Ray, D. Widera, A. L. David, T. B. Huber, J. Dengjel, P. De Coppi and K. Patel (2017). “Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis.” Stem Cells Dev 26(18): 1316-1333.

Mitchell, R., B. Mellows, J. Sheard, M. Antonioli, O. Kretz, D. Chambers, M. T. Zeuner, J. E. Tomkins, B. Denecke, L. Musante, B. Joch, F. Debacq-Chainiaux, H. Holthofer, S. Ray, T. B. Huber, J. Dengjel, P. De Coppi, D. Widera and K. Patel (2019). “Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins.” Stem Cell Res Ther 10(1): 116.

Neu, J. and W. A. Walker (2011). “Necrotizing enterocolitis.” N Engl J Med 364(3): 255-264.

Phinney, D. G. and M. F. Pittenger (2017). “Concise Review: MSC-Derived Exosomes for Cell-Free Therapy.” Stem Cells 35(4): 851-858.

Pinho, A. G., J. R. Cibrão, N. A. Silva, S. Monteiro and A. J. Salgado (2020). “Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders.” Pharmaceuticals (Basel) 13(2).

Ramos-Zaldívar, H. M., I. Polakovicova, E. Salas-Huenuleo, A. H. Corvalán, M. J. Kogan, C. P. Yefi and M. E. Andia (2022). “Extracellular vesicles through the blood-brain barrier: a review.” Fluids Barriers CNS 19(1): 60.

Ranganath, S. H., O. Levy, M. S. Inamdar and J. M. Karp (2012). “Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease.” Cell Stem Cell 10(3): 244-258.

Schmauch-Medina, T., A. Moliere, S. Lautrup, J. Zhang, S. Chlopicki, A. Borland Madsen, S. Cao, C. Soendenbroe, E. Mansell, H. B. Vestergaard, Z. Li, Y. Shiloh, P. L. Opresko, J. M. Egly, T. Kirkwood, E. Verdin, V. A. Bohr, L. S. Cox, T. Stevnsner, L. J. Rasmussen and E. F. Fang (2022) “New hallmarks of ageing: A 2022 Copenhagen ageing meeting summary” Aging Volume 14, Issue 16, pp6829-6839.

Stoll, B. J., N. I. Hansen, E. F. Bell, S. Shankaran, A. R. Laptook, M. C. Walsh, E. C. Hale, N. S. Newman, K. Schibler, W. A. Carlo, K. A. Kennedy, B. B. Poindexter, N. N. Finer, R. A. Ehrenkranz, S. Duara, P. J. Sánchez, T. M. O’Shea, R. N. Goldberg, K. P. Van Meurs, R. G. Faix, D. L. Phelps, I. D. Frantz, 3rd, K. L. Watterberg, S. Saha, A. Das and R. D. Higgins (2010). “Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network.” Pediatrics 126(3): 443-456.

Thomas, E. D., C. D. Buckner, R. A. Clift, A. Fefer, F. L. Johnson, P. E. Neiman, G. E. Sale, J. E. Sanders, J. W. Singer, H. Shulman, R. Storb and P. L. Weiden (1979). “Marrow transplantation for acute nonlymphoblastic leukemia in first remission.” N Engl J Med 301(11): 597-599.

Tower, J. (2015) “Programmed cell death in aging”. Ageing Res. Rev. Sep; 23(Pt A): 90-100

Tran, C. and M. S. Damaser (2015). “Stem cells as drug delivery methods: application of stem cell secretome for regeneration.” Adv Drug Deliv Rev 82-83: 1-11.

Wu, M., M. Wang, H. Jia and P. Wu (2022). “Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy.” Drug Deliv 29(1): 2513-2538.

Zhang, G., Q. Gao, S. Chen and Y. Chen (2019). “Primary cardiac synovial sarcoma that was continuous with the mitral valve caused severe thrombocytopenia: a case report.” J Cardiothorac Surg 14(1): 30.

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